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崙棫戝妛朄恖丗帬夑堛壢戝妛
戝妛徯夘 島嵗丒巤愝 擖帋忣曬 嫵堢丒尋媶 嶻妛楢実 崙嵺楢実 妛惗惗妶 晬懏昦堾
 

帬夑堛壢戝妛TOP > 嫵堢丒尋媶 > 嵟怴尋媶榑暥偺徯夘

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嵟怴尋媶榑暥偺徯夘
2016擭俉寧30擔 峏怴
Xiaoling Pang, Akio Shimizu, Souichi Kurita S, Dimitar P. Zankov, Keisuke Takeuchi, Mako Yasuda-Yamahara, Shinji Kume, Tetsuo Ishida, Hisakazu Ogita.
Novel Therapeutic Role for Dipeptidyl Peptidase III in the Treatment of Hypertension.

Hypertension. 2016; 68: 630-641. Doi: 10.1161/HYPERTENSIONAHA.116.07357.


崅寣埑帯椕偵偍偗傞儁僾僠僪暘夝峺慺Dipeptidyl peptidase III偺怴偨側栶妱

丂惗妶廗姷昦偺戙昞揑幘姵偱偁傞崅寣埑偵懳偟偰丄尰嵼傑偱偵條乆側庬椶偺崀埑栻偑奐敪偝傟椪彴墳梡偝傟偰偄傞傕偺偺丄擔杮傪娷傓愭恑崙偱偼崅寣埑姵幰悢偼憹壛偺堦搑偱偁傞丅偙偺偙偲偼婛懚偺帯椕栻偱廫暘偱偼側偔丄偝傜偵怴偨側婡彉偺崀埑栻偑昁梫偱偁傞偲偄偆偙偲傪堄枴偟偰偄傞丅DPP III乮Dipeptidyl peptidase III乯偼暘巕検栺80kDa偺僞儞僷僋幙偱偁傝丄3偐傜10傾儈僲巁偱峔惉偝傟傞億儕儁僾僠僪偺偆偪丄摿掕偺攝楍傪帩偮億儕儁僾僠僪偺N枛抂2巆婎傪暘夝偡傞儁僾僠僪暘夝峺慺偱偁傞丅偙傟傑偱偵丄DPP III偑傾儞僕僆僥儞僔儞II乮傾儈僲巁8巆婎偐傜側傞億儕儁僾僠僪乯傪暘夝偱偒傞偲偺曬崘偼偁偭偨傕偺偺丄偦偺徻嵶偵偮偄偰偼慡偔晄柧偱偁偭偨丅

丂DPP III偑傾儞僕僆僥儞僔儞II傪暘夝偡傞峺慺妛揑摿惈偺徻嵶傪柧傜偐偵偟偨乮儈僇僄儕僗掕悢Km = 3.7 亊 10亅6mol/L丄嵟戝斀墳懍搙Vmax = 3.3 亊 10亅9 mol/L/sec乯丅師偵丄傾儞僕僆僥儞僔儞II晧壸偵傛傝崅寣埑忬懺偵偟偨儅僂僗偵DPP III傪旜惷柆偐傜搳梌偡傞偲丄桳堄偵寣埑偑掅壓偟偨丅傑偨丄惷柆搳梌偟偨DPP III偼丄栺1擔偱懱撪偐傜傎傏徚幐偟偨丅DPP III偵傛傞崀埑岠壥偼丄僲儖傾僪儗僫儕儞晧壸偵傛傞崅寣埑儅僂僗傗丄惓忢寣埑儅僂僗偱偼尒傜傟側偐偭偨偙偲偐傜丄傾儞僕僆僥儞僔儞II摿堎揑側嶌梡偱偁傞偲峫偊傜傟偨丅

丂傾儞僕僆僥儞僔儞II晧壸偺弶婜偐傜DPP III傪2擔偵1夞偢偮挿婜娫楢懕搳梌偟偨応崌丄傾儞僕僆僥儞僔儞II偵傛傞崅寣埑傪梷惂偱偒偨丅崅寣埑偑帩懕偡傞偲丄怱憻偱偼怱旍戝傗慄堐壔丄恡憻偱偼擜拞傾儖僽儈儞攔煏検偑憹壛偡傞側偳條乆側憻婍忈奞偑惗偠傞偑丄DPP III傪挿婜娫楢懕搳梌偡傞偲偙傟傜偺憻婍忈奞傪梷惂偡傞偙偲偑偱偒偨丅偙偺條側DPP III偺嶌梡偵偮偄偰偼丄傾儞僕僆僥儞僔儞庴梕懱漢峈栻僇儞僨僒儖僞儞偲摨摍埲忋偱偁偭偨丅

丂偙偺傛偆偵杮尋媶偱偼丄DPP III偺傾儞僕僆僥儞僔儞II暘夝偵偍偗傞峺慺妛揑摿惈偺徻嵶傪柧傜偐偵偡傞偲嫟偵丄悽奅偱弶傔偰DPP III偑崅寣埑摦暔儌僨儖偱崀埑嶌梡傪敪婗偡傞偙偲傪撍偒巭傔偨丅偝傜偵丄DPP III偺挿婜搳梌偱崅寣埑偐傜憻婍傪曐岇偱偒傞偙偲傪幚徹偟偨丅


暥愑丂惗壔妛丒暘巕惗暔妛島嵗乮暘巕昦懺惗壔妛乯丂愵揷丂媣榓

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in vivo 偱偺siRNA銷泖撪拲擖椕朄偵傛傞偑傫憹怋梷惂偵悽奅偱弶傔偰惉岟
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The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels.
Conserved role of nanos proteins in germ cell development.
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岎捠丒傾僋僙僗 僉儍儞僷僗儅僢僾 偍栤偄崌偣愭 僒僀僩儅僢僾 偙偺僒僀僩偵偮偄偰
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