| 2011擭9寧12擔
峏怴 |
| Hagiwara T, Mukaisho K, Nakayama T, Sugihara H, Hattori T. |
| Long-term proton pump inhibitor administration worsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infected with Helicobacter pylori. |
| Gut. 2010 Nov 20. [Epub ahead of print] 丂 PMID: 21097844 |
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| 僿儕僐僶僋僞乕丒僺儘儕姶愼僗僫僱僘儈偵偍偄偰丄PPI挿婜搳梌偼堔弅惈堓墛傪憺埆偝偣態娻偺敪惗傪懀恑偡傞 |
亂梫巪亃
Helicobacter pylori乮H. pylori乯姶愼姵幰偵Proton pump inhibitor乮PPI乯傪挿婜搳梌偡傞偲丄堓懱晹偺堔弅惈堓墛偑憹埆偡傞偲偺曬崘偑偁傞丅変乆偼H. pylori姶愼僗僫僱僘儈偵PPI挿婜搳梌傪峴偄丄堓擲枌偵偍偙傞曄壔傪慻怐妛揑偵専摙偟偨丅
奺孮15旵偺僗僫僱僘儈傪4孮偵暘椶偟偨丅OPZ+Hp僌儖乕僾偲Hp僌儖乕僾偵偼H.pylori(ATCC43504)傪姶愼偝偣丄OPZ+Hp僌儖乕僾偲OPZ僌儖乕僾偵偼PPI乮Omeprazole乯傪搳梌偟丄僐儞僩儘乕儖僌儖乕僾偼柍張抲偲偟偨丅PPI偼1擔栺100 mg/kg傪愛庢偡傞傛偆偵塧偵崿偤偰6儢寧娫搳梌偟偨丅PPI搳梌奐巒帪婜偼丄墛徢偑堓懱晹偵傑偱攇媦偟巒傔傞H.pylori姶愼6儢寧屻偲偟偨丅
僗僫僱僘儈傪搄嶦屻丄堓傪戝淾愗奐偟丄堓掙態椞堟傪6摍暘丄桯栧態椞堟傪3摍暘偟丄寁9暘妱偟偨丅6愗曅偺堓掙態椞堟偵懳偟偰丄HE愼怓昗杮傪梡偄偰慻怐妛揑偵堔弅偺妱崌傪應掕偟丄僗僐傾壔偟偨丅堓掙態椞堟偵偍偗傞暻嵶朎偺姰慡側寚擛傪傕偭偰堔弅偲敾掕偟偨丅擲枌壓偵敪惗偡傞堎宆偺側偄態娗傪堎強惈態娗偲偟丄偦傟偲偼堎側傝妀堎宆偲峔憿堎宆傪敽偆態娗傪態娻偲掕媊偟偨丅
亂寢壥媦傃峫嶡亃OPZ+Hp僌儖乕僾偱偼丄Hp僌儖乕僾偵斾傋丄傛傝嫮偄堓掙態椞堟偺堔弅傪擣傔偨丅堎強惈態娗偼OPZ+Hp僌儖乕僾乮15/15旵乯偲Hp僌儖乕僾乮14/15旵乯偵擣傔傜傟偨丅堦曽丄崅暘壔宆態娻偑OPZ+Hp僌儖乕僾乮9/15旵乯偲Hp僌儖乕僾乮1/15旵乯偵擣傔傜傟丄偦偺懠偺孮偱偼丄態娻偺敪惗偼擣傔側偐偭偨丅
埲忋傛傝H. pylori姶愼忬懺偱偼丄PPI挿婜搳梌偵傛傝堔弅惈堓墛偺埆壔偑偍偙傝丄態娻偺敪惗傪懀恑偡傞壜擻惈偑偁傞偙偲偑帵嵈偝傟偨丅偙傟傜偺寢壥偐傜丄PPI挿婜搳梌傪峫椂偡傞応崌偵偼丄傑偢丄H. pylori偺桳柍傪専嵏偟丄梲惈偱偁傟偽彍嬠屻偵PPI偺挿婜搳梌偡傞偙偲偑朷傑傟傞偲寢榑偟偨丅
暥愑丂昦棟妛島嵗丂暘巕恌抐昦棟妛晹栧丂岦強丂尗堦
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