| Nogawa M, Yuasa T, Kimura S, Tanaka M, Kuroda J, Sato K, Yokota A,
Segawa S, Toda Y, Kageyama S, Yoshiki T, Okada Y,
Maekawa |
| Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer |
| J Clin Invest.2005;115:978-985
PMID: 15761500 |
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| in vivo 偱偺siRNA銷泖撪拲擖椕朄偵傛傞偑傫憹怋梷惂偵悽奅偱弶傔偰惉岟 |
亂梫巪亃
small interfering RNA (siRNA) 偼攝楍摿堎揑偵慖戰揑偵堚揱巕偺敪尰偺惂屼傪偍偙側偄師悽戙偺暘巕昗揑帯椕偲偟偰婜懸偝傟偰偄傑偡丅偟偐偟側偑傜廫暘検偺 siRNA 傪昗揑偵摓払偝偣傞 drug delivery system (DDS) 偑妋棫偝傟偰偄側偄偙偲偵傛傝丄偙傟傑偱in vivo偵偍偗傞惉岟椺偺曬崘偑朢偟偔丄椪彴墳梡傊偺忈奞偲側偭偰偄傑偡丅崱夞丄傢傟傢傟偼DDS偺栤戣偑斾妑揑彮側偄銷泖偲偄偆暵嵔嬻娫傪嶌傝弌偟摼傞晹埵偵拝栚偟丄儅僂僗銷泖撪偵堏怉偝傟偨銷泖偑傫偵懳偟偰siRNA偺拲擖椕朄傪峴偄傑偟偨丅宱擜摴揑偵siRNA傪拲擖偡傞偙偲偵傛傝丄偑傫嵶朎偺憹怋偵廳梫側摥偒傪偡傞堚揱巕PLK-侾偺摥偒傪梷惂偡傞偙偲偵傛偭偰丄銷泖撪偱庮釃偺憹怋傪梷惂偟丄偑傫嵶朎偺傾億僩乕僔僗傪桿摫偡傞偙偲傪妋擣偟傑偟偨丅杮尋媶偼崱屻偺siRNA偺妀巁堛栻偲偟偰偺椪彴墳梡傊偺壜擻惈傪帵嵈偡傞偲偄偆揰偱廳梫偱偡丅銷泖娻偵懳偡傞siRNA儕億僜乕儉暋崌懱偵傛傞宱擜摴揑帯椕傪in vivo偱幚慔偟偨偺偼変乆偺抦傞尷傝悽奅偱桞堦偱偡丅崱屻偼丄懠栻嵻傗siRNA側偳偺暪梡偵傛傞偝傜側傞帯椕岠壥偺岦忋偲偲傕偵丄僽僞銷泖側偳偵傛傞埨慡惈偺妋擣傪恑傔偰偄偒偨偄偲巚偄傑偡丅
暥愑丂帬夑堛壢戝妛9婜惗丄尰嵼廐揷戝妛斿擜婍壢丂搾愺丂寬 |
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