| 2013擭7寧31擔 峏怴 |
| Akiko Kojima, Hirotoshi Kitagawa, Mariko Omatsu-Kanbe, Hiroshi Matsuura, Shuichi Nosaka, |
| Sevoflurane Protects Ventricular Myocytes Against Oxidative Stress-Induced Cellular Ca2+ Overload and Hypercontracture |
Anesthesiology 2013 Sep; 119:606-20. |
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僙儃僼儖儔儞偼妶惈巁慺偵傛傞怱嬝彎奞傪梷惂偟偰嫊寣嵞燇棳彎奞偐傜怱憻傪曐岇偡傞 |
丂嫊寣偵娮偭偨怱嬝傪媬嵪偡傞偨傔偵偼姤忬摦柆偺寣棳偺嵞奐乮嵞燇棳乯偑昁恵偱偁傞偑丆偙偺嫊寣怱嬝偺嵞燇棳偼昁偢偟傕怱婡擻偺夞暅偵偮側偑傞偲偼尷傜偢丆媡偵晄惍柆乮嵞燇棳晄惍柆乯丆廂弅婡擻偺夞暅抶墑乮stunned myocardium乯丆偝傜偵偼怱嬝嵶朎巰乮reperfusion-induced cell death乯摍偺偝傑偞傑側彎奞傪敽偆偙偲偑抦傜傟偰偄傞乮怱嬝嫊寣嵞燇棳彎奞乯丅
丂堦曽丆僙儃僼儖儔儞丆僀僜僼儖儔儞丆僨僗僼儖儔儞側偳偺媧擖杻悓栻偼嫊寣嵞燇棳彎奞偐傜怱嬝傪曐岇偡傞偙偲偑抦傜傟偰偄傞丅杮尋媶偼丆怱嬝嫊寣嵞燇棳彎奞偺敪惗偵枾愙偵娭梌偡傞偲峫偊傜傟偰偄傞妶惈巁慺乮夁巁壔悈慺乯偵傛傞嵶朎撪Ca2+夁晧壸傪幚尡儌僨儖偲偟偰梡偄偰丆僙儃僼儖儔儞偺怱嬝曐岇嶌梡傪専摙偟偨傕偺偱偁傞丅
丂偦偺寢壥丆夁巁壔悈慺偼 1) 嬝彫朎懱儕傾儞僕儞庴梕懱乮RyR2乯偐傜偺Ca2+儕乕僋傪懀恑偡傞偙偲丆2) Ca2+/僇儖儌僕儏儕儞埶懚惈僞儞僷僋僉僫乕僛乮CaMKII乯偺妶惈壔傪夘偟偰L宆Ca2+揹棳乮ICa,L乯傪憹嫮偡傞偙偲偵傛傝怱嬝嵶朎偵晄壜媡揑側Ca2+夁晧壸傪桿敪偟嵶朎巰傪庝婲偡傞偙偲偑傢偐偭偨丅椪彴巊梡擹搙偺僙儃僼儖儔儞偼丆RyR2偐傜偺Ca2+儕乕僋丆CaMKII偺妶惈壔丆ICa,L偺憹嫮丆偺偄偢傟偵懳偟偰傕梷惂嶌梡傪敪婗偟偰丆夁巁壔悈慺偵傛傞Ca2+夁晧壸偺敪惗傪梷偊偰怱嬝嵶朎傪曐岇偡傞偙偲偑傢偐偭偨丏丅
寢榑丗怱嬝嫊寣嵞燇棳彎奞偼丆庡偵怱嬝嵶朎偺Ca2+桝憲僞儞僷僋幙乮RyR2丆ICa,L乯傗偦偺挷愡場巕乮CaMKII乯偺婡擻偑槾恑偟偰嵶朎撪Ca2+儂儊僆僗僞乕僔僗偺攋抅傪偒偨偡偙偲偑尨場偲峫偊傜傟偨丅傑偨丆僙儃僼儖儔儞偼偙傟傜偺Ca2+桝憲僞儞僷僋幙側傜傃偵偦偺挷愡場巕偵嶌梡偟偰嵶朎撪Ca2+惂屼婡峔傪惓忢壔偡傞偙偲偵傛傝丆怱嬝嵶朎傪嫊寣嵞燇棳彎奞偐傜曐岇偡傞偲峫偊傜傟偨丅偙偺僙儃僼儖儔儞偺嶌梡偼丆嫊寣惈怱幘姵偺怱嬝曐岇栻偺奐敪偵怴偨側忣曬傪採嫙偡傞壜擻惈偑偁傞丅
暥愑丂丂杻悓妛島嵗 彫搱丂垷婓巕 |
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