| Kawasaki M, Maeda T, Hanazawa K, Ohkubo I, Tani T. |
| Effect of His-Gly-Lys Motif Derived from Domain 5 of High Molecular Weight Kininogen
on Suppression of Cancer Metastasis Both in vitro and in vivo. |
| J Biol Chem. 2003;278:49301-49307
PMID: 14506238
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| 崅暘巕僉僯僲乕僎儞丒僪儊僀儞俆拞偺His-Gly-Lys攝楍偑娻嵶朎偺揮堏傪梷惂偡傞 |
亂梫巪亃
崅暘巕僉僯僲乕僎儞偼僪儊僀儞峔憿傪帩偮懡婡擻惈寣燋僞儞僷僋幙偱偁傞丅変乆偼丄攟梴嵶朎傪梡偄丄 愙拝慾奞妶惈偲婎掙枌怹弫慾奞妶惈傪巜昗偲偟偰崅暘巕僉僯僲乕僎儞偺僪儊僀儞俆偵懚嵼偡傞娻嵶朎揮 堏慾奞椞堟偺扵嶕傪峴偭偰偒偨丅
崱夞丄偦偺娻嵶朎揮堏慾奞椞堟偺僐傾攝楍偑俁偮偺傾儈僲巁攝楍His-Gly-Lys偵峣傜傟傞偙偲傪丄 崌惉儁僾僠僪傗僪儊僀儞俆偺慻姺偊僞儞僷僋幙傪梡偄偰in vitro偲in vivo偺幚尡宯偱柧傜偐偵偟偨丅 His-Gly-Lys攝楍偺Lys巆婎傪摨偠億僕僥傿僽僠儍乕僕傪帩偮Arg巆婎偵抲姺乮His-Gly-Arg攝楍乯 偡傞偲丄愙拝傗婎掙枌怹弫偑慾奞偝傟側偔側傞偙偲乮攟梴嵶朎傪梡偄偨幚尡乯丄崅揮堏惈娻嵶朎偺 攛揮堏慾奞偑尒傜傟側偔側傞偙偲乮儅僂僗傪梡偄偨幚尡揑攛揮堏慾奞幚尡乯偐傜丄偙傟傜偺慾奞妶惈偺 僐傾攝楍偑傾儈僲巁攝楍偵埶懚偟偰偄傞偙偲傪帵偟偨丅偝傜偵丄暘巕検栺95kDa偺枌僞儞僷僋幙偑丄 His-Gly-Lys攝楍偵寢崌偡傞姅壔娻嵶朎忋偺儗僙僾僞乕偱偁傞壜擻惈傕帵偟偨丅偟偐偟丄寣娗撪旂嵶朎偺 娗宍惉偼丄偙偺His-Gly-Lys攝楍偱偼慾奞偝傟側偐偭偨丅
崅暘巕僉僯僲乕僎儞丒僪儊僀儞俆偺His-Gly-Lys攝楍晅嬤偼丄億僕僥傿僽僠儍乕僕傪帩偮傾儈僲巁偑 70%埲忋偺昿搙偱懚嵼偡傞偨傔丄僠儍乕僕傪夘偟偰嵶朎昞柺偵僪儊僀儞俆偑寢崌偟怓乆側嵶朎婡擻傪 慾奞偡傞偲峫偊傜傟偰偒偨偑丄変乆偼His-Gly-Lys攝楍偑嵶朎昞柺偺儗僙僾僞乕偵寢崌偡傞偙偲偵傛傝 娻嵶朎偺揮堏偑慾奞偝傟傞偙偲傪尒偄弌偟偨丅偙偺尰徾偼His-Gly-Lys攝楍偽偐傝偱偼側偔丄 His-Gly-Lys峔憿椶帡偺栻嵻偑娻揮堏傪梷偊傞壜擻惈傪帵嵈偟偰偄傞丅
惗壔妛戞擇島嵗 |
