| 2011擭9寧12擔
峏怴 |
| Kaida S,Horacio C, Kumagai M, Kishimura A, Terada Y, Sekino M, Aoki I, Nishiyama N, Tani T, Kataoka K. |
| Visible-drug delivery by supra-molecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. |
| Cancer Research 70(18);7031-41.2010 丂 PMID: 20685894 |
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| 扨堦僾儔僢僩僼僅乕儉忋偵恌抐栻偲帯椕栻傪搵嵹偟偨挻暘巕僫僲僉儍儕傾偵傛傞壜帇壔僪儔僢僌僨儕僶儕乕偺丄鋁娻儌僨儖傪梡偄偨昡壙 |
亂梫巪亃
丂娻帯椕偱偺帯椕栻傗恌抐栻傪娻摿堎揑偵憲払偡傞偙偲偺偱偒傞僪儔僢僌僨儕僶儕乕僔僗僥儉(DDS) 偵偍偄偰丄峈娻嵻偲MRI憿塭嵻偺椉曽傪摨帪偵撪曪偟偨崅暘巕儈僙儖傪嶌惉偡傞偙偲偱丄栚偵尒偊傞栻嵻(visible-DDS)傪奐敪偟丄娻帯椕偺怴偟偄奣擮傪妋棫偟偨丅
亂曽朄亃
丂DACHPt(妶惈宆oxaliplatin)撪曪崅暘巕儈僙儖傪儌僨儖偲偟丄嶌惉抜奒偱MRI憿塭嵻偺Gd-DTPA傪寢崌偝偣丄DACHPt/Gd-DTPA撪曪崅暘巕儈僙儖傪嶌惉偟偨丅扴娻儅僂僗乮戝挵娻(C26)旂壓堏怉儌僨儖偍傛傃僸僩鋁憻娻(BxPC3)摨強乮鋁撪乯堏怉儌僨儖乯傪嶌惉偟丄MRI憿塭岠壥偲峈庮釃岠壥傪妋擣偟偨丅寀岝X慄夝愅朄偱Pt尨巕偍傛傃Gd尨巕偺庮釃撪懚嵼傪妋擣偟偨丅
亂寢壥偍傛傃峫嶡亃
丂DACHPt/Gd-DTPA撪曪崅暘巕儈僙儖偼Enhenced Permeability and Retention (EPR)岠壥傪棙梡偟偰庮釃撪偵慖戰揑偵憲払偱偒傞僒僀僘偱丄寣拞懾棷惈傕挿偔丄栻嵻彊曻弌惈傕妋擣偝傟偨丅MRI憿塭嵻偺憿塭擻椡偺巜昗偱偁傞乽娚榓擻乿偑僼儕乕偺Gd-DTPA(3.4 mM-1S-1)偵斾傋偰20攞傕偺崅偄抣(80.7 mM-1S-1)傪帵偟偨丅in vitro帋尡偱偺惂娻嶌梡偺昡壙偱偼丄儈僙儖偼摨擹搙偺oxaliplatin偲斾傋懟怓側偄惂娻嶌梡傪桳偟偨丅儅僂僗戝挵娻嵶朎旂壓堏怉儌僨儖偍傛傃僸僩鋁娻摨強堏怉儌僨儖偵偍偄偰丄MRI偵傛傞挊柧偐偮帩懕揑側庮釃憿塭岠壥傪帵偟丄control孮偍傛傃oxaliplatin搳梌孮偵斾傋丄桳堄偵庮釃偺惉挿傪梷惂偟偨丅SPring8偱偺寀岝X慄夝愅偱偼丄庮釃撪偵Pt偍傛傃Gd偑慖戰揑偵庢傝崬傑傟偰偍傝丄椉栻嵻偺co-localize偑徹柧偝傟偨丅
亂寢榑亃
丂DACHPt/Gd-DTPA撪曪儈僙儖偼丄庮釃偵慖戰揑偵帯椕栻偲恌抐栻傪憲払偡傞乽栚偵尒偊傞DDS乿偲偄偆怴偟偄奣擮傪懪偪棫偰丄師悽戙偺娻帯椕栻偲偟偰椪彴墳梡偑婜懸偝傟傞僫僲僨僶僀僗偱偁傞丅
暥愑丂帬夑堛壢戝妛奜壢妛島嵗丂奓揷丂嵅抦巕
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