| 2011擭1寧11擔
峏怴 |
| Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, Nakayama H, Miyagi Y, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y* |
| Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. ** |
| Cancer Res. 2010;70:5326-36. 丂 PMID: 20551066 |
| 峈Dickkopf-1 (DKK1)峈懱偼娻嵶朎偐傜暘斿偝傟偨DKK1僞儞僷僋婡擻傪拞榓偟偰娻嵶朎偵傾億僩乕僔僗傪桿摫偡傞 |
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| Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y* |
| Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. *** |
| Cancer Res. 2010;70:5337-47. 丂 PMID: 20551060 |
| CDCA5僞儞僷僋桼棃偺嵶朎枌摟夁惈儁僾僠僪偼ERK僉僫乕僛偵傛傞CDCA5偺儕儞巁壔傪慖戰揑偵慾奞偟娻嵶朎偺憹怋傪梷惂偡傞 |
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| 乮*Corresponding author丄**僆乕僟乕儊僀僪堛椕幚尰壔僾儘僕僃僋僩乮帬夑堛戝昦堾傪娷傓12堛椕婡娭乯帋椏傪梡偄偨尋媶丄***暷崙娻妛夛(AACR) 100th Annual Meeting, Scholar-In-Training Awards庴徿尋媶乯 |
亂梫巪亃
埆惈庮釃偵懳偡傞怴婯偺峈懱堛栻偲儁僾僠僪堛栻偺奐敪偵岦偗偨尋媶丗峈DKK1峈懱偲嵶朎枌摟夁惈CDCA5桼棃儁僾僠僪偺峈庮釃岠壥傪専徹
峈懱堛栻
丂娻嵶朎摿堎揑偵敪尰偡傞嵶朎枌僞儞僷僋丄娻嵶朎憹怋場巕偲偟偰摥偔暘斿僞儞僷僋偼峈懱堛栻偺桳梡側帯椕昗揑暘巕偲峫偊傜傟傞丅変乆偼暘斿僞儞僷僋DKK1偑攛娻丄怘摴娻丄堓娻丄娞娻丄抇娗娻丄鋁娻丄擕娻丄巕媨寊娻慻怐偱崅儗儀儖偵敪尰偟丄姵幰寣惔拞偱崅抣傪帵偟偰寣惔恌抐僶僀僆儅乕僇乕偲偟偰桳梡偱偁傞偙偲傪帵偟偨丅峈DKK1峈懱傪攟梴塼拞偵揧壛偡傞偙偲偵傛傝娻嵶朎偺傾億僩乕僔僗偑桿摫偝傟傞偙偲丄傑偨儅僂僗偵堏怉偟偨娻嵶朎偼峈DKK1峈懱偺慡恎搳梌偵傛傝憹怋偑梷惂偝傟傞偙偲偐傜丄DKK1傪夘偟偨僔僌僫儖揱払宱楬偼娻偺峈懱椕朄偺桳朷側昗揑偲峫偊傜傟傞丅
儁僾僠僪堛栻
丂 攛娻偺僎僲儉儚僀僪側堚揱巕敪尰忣曬夝愅偵傛傝帯椕昗揑暘巕偲側傞oncoprotein偲偟偰CDCA5 (cell-division-associated 5)傪摨掕偟丄262椺偐傜側傞攛娻慻怐儅僀僋儘傾儗僀夝愅偵傛傝CDCA5偑崅儗儀儖偵敪尰偟偰偄傞徢椺偼桳堄偵梊屻晄椙偱偁傞偙偲傪帵偟偨丅傑偨CDCA5偼ERK (extracellular signal-regulated kinase)偵傛傝丄Serine 209偱儕儞巁壔傪庴偗偰丄娻嵶朎偺憹怋偵娭傢傞偙偲傪柧傜偐偵偟偨丅偦偙偱CDCA5偺Serine 209傪娷傓20傾儈僲巁偲11屄偺Arginine乮枌摟夁惈攝楍乯傪梈崌偟偨嵶朎枌摟夁惈儁僾僠僪傪崌惉偟偰攛娻嵶朎姅偺攟梴塼拞偵揧壛偟偨偲偙傠丄ERK偵傛傞CDCA5偺慖戰揑儕儞巁壔偑嫞崌揑偵慾奞偝傟丄娻嵶朎偺憹怋偑梷惂偝傟偨丅埲忋偺寢壥傛傝丄CDCA5偲ERK偺峺慺婎幙斀墳傪慖戰揑偵慾奞偡傞儁僾僠僪堛栻傗掅暘巕壔崌暔偼丄暃嶌梡偺彮側偄桳朷側攛娻帯椕栻偲側傞壜擻惈偑帵嵈偝傟偨丅
暥愑丂憤崌偑傫帯椕妛島嵗丒庮釃撪壢丂戠岉丂栱懢榊
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