2010擭2寧26擔
峏怴 |
Itoh H, Sakaguchi T, Ding WS, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M |
Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome |
Circulation Arrhythmia & EP 2;511-23,2009. PMID: 19843919 |
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栻嵻偵傛傞QT墑挿偲抳巰惈晄惍柆偺堚揱揑攚宨 |
亂梫巪亃
壗傜偐偺栻嵻傪撪暈屻偵抳巰惈晄惍柆僀儀儞僩(torsade de pointes)傪擣傔偨20徢椺乮暯嬒擭楊65嵨乯傪懳徾偵堚揱巕専嶕傪巤峴偟偨寢壥丄8椺乮20%乯偵堚揱巕曄堎傪擣傔偨丅偙偺昿搙偼愭揤惈QT墑挿徢岓孮偺敪抂幰偵偍偗傞摨掕棪乮52%乯偲嵎傪擣傔側偐偭偨丅堦曽丄峈晄惍柆栻偺撪暈偱敪徢偟偨徢椺偵偍偗傞堚揱巕曄堎摨掕棪偼丄峈晄惍柆栻埲奜偺栻嵻偵傛傞敪徢徢椺傛傝桳堄偵掅棪偱偁偭偨乮21% vs. 83%, p<0.05乯丅歁擕椶嵶朎傪梡偄偨嫮惂敪尰幚尡偱偺婡擻夝愅偵傛傝丄偙傟傜偺曄堎偼寉旝側揹棳尭彮傗僎乕僥傿儞僌偺曄壔傪桳偟偰偄偨丅妶摦揹埵帩懕帪娫偺僔儈儏儗乕僔儑儞偱偼丄栻嵻惈QT墑挿徢岓孮偱擣傔偨曄堎僠儍僱儖偺摿惈傪桳偡傞怱嬝妶摦揹埵偼惓忢偲愭揤惈QT墑挿徢岓孮偺拞娫偵埵抲偟偨丅
埲忋偺偙偲偐傜丄栻嵻惈QT墑挿徢岓孮偼偄傢備傞乬晄姰慡宆乭QT墑挿徢岓孮偺堦庬偱偁傝丄愽嵼揑偵桳偡傞婡擻堎忢偵傛傝嵞暘嬌梊旛擻乮repolarization reserve乯偑幐傢傟偰偄傞偙偲偑敪徢偵娭梌偟偰偄傞偲峫偊傜傟偨丅
暥愑丂弞娐婍撪壢丂埳摗丂塸庽丒杧峕丂柅 |
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