| Keizo Kanasaki, Kristin Palmsten, Hikaru Sugimoto, Shakil Ahmad, Yuki Hamano, Liang Xie, Samuel Parry, Hellmut G. Augustin, Vincent H. Gattone Jr, Judah Folkman, Jerome F. Strauss, Raghu Kalluri |
| Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. |
| Nature. 2008 May 11. [Epub ahead of print] PMID: 18469803 |
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亂梫巪亃
Pre-eclampsia乮PE: 巕釖慜徢乯偺徻嵶偼晄柧偱摿堎揑帯椕朄偼妋棫偟偰偄側偄丅嬥嶈傜偼丄catechol-O-methyltransferase (COMT)僲僢僋傾僂僩儅僂僗偑擠怭帪偵PE條徢忬傪掓偡傞偙偲傪尒弌偟偨丅COMT偼僇僥僐乕儖傾儈儞傪晄妶壔偡傞偺傒偱側偔丄estradiol偐傜2-methoxyestradiol (2-ME)傪嶻惗偡傞丅2-ME偼丄hypoxia-inducible factor (HIF)-1兛偺嫮椡側慾奞場巕偱偁傝丄惓忢擠怭屻婜偱媫寖偵寣拞擹搙偑忋徃偡傞丅偦偙偱嬥嶈傜偼丄2-ME寚朢偵傛偭偰丄HIF-1兛偍傛傃偦偺HIF-1兛偵傛偭偰挷愡傪偆偗傞戀斦嫊寣偵婲場偡傞壜梟惈暔幙乮soluble Fms-like tyrosine kinase-1 (sFLT-1)側偳乯偑柍拋彉偵敪尰偡傞偙偲偑PE偺庡昦懺偱偁傞偲峫偊偨丅帠幚丄栰惗宆偵斾偟擠怭COMT僲僢僋傾僂僩儅僂僗偵偍偄偰丄寣燋2-ME擹搙偼挊柧偵掅壓偟偰偍傝丄2-ME搳梌偵傛傝擠怭COMT僲僢僋傾僂僩儅僂僗偺戀斦嫊寣偵傛傝庝婲偝傟傞HIF-1兛, sFLT-1敪尰偺掅壓偲偲傕偵PE條徢忬偼夵慞偟偨丅偝傜偵丄僸僩偵偍偄偰傕丄PE椺偱偼惓忢擠怭幰偵斾偟丄寣燋2-ME擹搙掅壓偟偰偄傞偙偲丄戀斦COMT抈敀敪尰偑掅壓偟偰偄偨丅尰嵼丄摑崌幐挷徢側偳惛恄恄宱幘姵偲偺憡娭偑抦傜傟偰偄傞COMT抈敀偺埨掕惈偵娭梌偡傞婡擻揑堚揱巕懡宆偵偮偄偰丄PE偵偍偗傞寣燋2-ME擹搙掅壓傗戀斦COMT敪尰掅壓偵娭梌偟偰偄傞偐斲偐戝婯柾椪彴僒儞僾儖傪梡偄偨夝愅偑峴傢傟偰偍傝丄怴偨側PE偺梊抦丒恌抐丒帯椕朄偑柧帵偝傟傞傕偺偲妋怣偟偰偄傞丅
嬥嶈孾憿愭惗偼杮妛12婜惗偱丄尰嵼傾儊儕僇偺 Beth Israel Deaconess Medical Center 偱妶桇拞偱偡
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