| 2010擭2寧26擔
峏怴 |
| Tomoya Terashima, Kazuhiro Oka, Angelika B. Kritz, Hideto Kojima, Andrew H. Baker and Lawrence Chan |
| DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice |
| J Clin Invest. 2009,July;119(7):2100-2112, URL丗http://www.jci.org/articles/view/39038 |
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| 儅僂僗屻崻恄宱愡傪昗揑偲偡傞僿儖僷乕埶懚宆傾僨僲僂僀儖僗儀僋僞乕偵傛傞姶妎恄宱嵶朎忈奞偺慖戰揑堚揱巕帯椕 |
亂梫巪亃
乽捝傒乿偺尨場偲側傞抦妎恄宱忈奞偼條乆側昦懺偱惗偠丄QOL傪戝偒偔掅壓偝偣傞梫場偲側偭偰偄傞丅尰嵼丄偦偺捝傒傪僐儞僩儘乕儖偡傞曽朄偲偟偰條乆側栻暔傗奜壢揑帯椕偑帋傒傜傟偰偄傞偑丄廫暘偵僐儞僩儘乕儖偱偒傞曽朄偼枹偩曬崘偝傟偰偼偄側偄丅
偦偙偱丄変乆偼丄椪彴揑桳梡惈偑拲栚偝傟偰偄傞僿儖僷乕埶懚宆傾僨僲僂僀儖僗儀僋僞乕乮HDAd, Kojima et al, Nat Med, 2003乯傪夵椙偟丄慻怐摿堎惈傪慻傒崬傓偙偲偵傛傝堦師姶妎恄宱嵶朎偱偁傞屻崻恄宱愡乮DRG乯僯儏乕儘儞傊偺摿堎揑堚揱巕桝憲僔僗僥儉偺奐敪傪峴偭偨丅
杮棃HDAd偑帩偭偰偄傞慻怐嫟捠寢崌晹埵傪庢傝彍偒丄怴偨偵変乆偑尒偄偩偟偨DRG偵摿堎揑偵寢崌偡傞儁僾僠僪乮Oi et al, Neuroscience letters, 2008乯傪憓擖偡傞偙偲偵傛傝DRG昗揑堚揱巕桝憲傪幚尰偝偣傞偙偲偵惉岟偟丄昗揑慻怐埲奜偱偺堚揱巕敪尰傪嵟彫尷偵梷偊偨丅偙傟偵傛傝丄僂僀儖僗儀僋僞乕偵懳偡傞柶塽斀墳傕嵟彫尷偵梷偊傜傟丄儀僋僞乕偺埨慡惈偼旘桇揑偵岦忋偟偨丅
傑偨丄偦偺惈擻傪柧傜偐偵偡傞偨傔偵丄塣摦宯偍傛傃姶妎宯傪娷傫偩慡恎偵恄宱忈奞偺弌尰偡傞儅僂僗乮Hexb KO mice乯偵堚揱巕帯椕傪峴偄丄DRG傪昗揑偲偟偨姶妎惈枛徑恄宱忈奞偺摿堎揑側堚揱巕帯椕偵惉岟偟偨丅
崱屻丄恄宱場惈醬捝傗摐擜昦惈恄宱忈奞 (Terashima et al, PNAS, 2005) 偵懳偟丄偙偺僔僗僥儉傪梡偄偨怴婯帯椕朄偺奐敪傪恑傔偰備偔丅傑偨丄崱夞嶌惉偟偨慻怐摿堎揑僿儖僷乕埶懚宆傾僨僲僂僀儖僗儀僋僞乕僔僗僥儉偼悽奅弶偱偁傝丄昗揑擣幆晹埵傪帺嵼偵擖傟懼偊傞偙偲偑偱偒傞偨傔丄條乆側幘姵傗憻婍傊偺斈梡惈偑崅偔丄堚揱巕桝憲僔僗僥儉偺媄弍傪戝偒偔桇恑偝偣傞傕偺偲妋怣偟偰偄傞丅
暥愑丂撪壢妛島嵗丂恄宱撪壢丂帥搰抭栫
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