| 2010擭5寧10擔
峏怴 |
| Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, Sugimoto T, Haneda M, Kashiwagi A, Koya D. |
| Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. |
| J Clin Invest. 2010 Apr 1;120(4):1043-55. PMID: 20335657 |
| 僇儘儕乕惂尷偵傛傞壛楊惈恡忈奞梷惂岠壥偵偍偗傞峈榁壔暘巕Sirt1-僆乕僩僼傽僕乕宱楬偺堄媊 |
亂梫巪亃
恡憻偼榁壔偵敽偆婡擻忈奞傪掓偡傞憻婍偺堦偮偱偁傞偑丄偦偺敪徢丒恑揥偵娭傢傞暘巕婡峔側傜傃偵梷惂婡峔偼柧傜偐偵偝傟偰偄側偄丅変乆偼僇儘儕乕惂尷乮CR乯偑丄條乆側惗暔庬偵偍偗傞庻柦墑挿岠壥偵壛偊丄壛楊偵敽偆恡忈奞傪梷惂偟偆傞帠偐傜丄偙偺暘巕婡峔偺夝柧偑壛楊惈恡忈奞偺怴偨側帯椕朄偺妋棫偵宷偑傞傕偺偲峫偊専摙傪峴偭偨丅
壛楊儅僂僗恡擜嵶娗嵶朎偱偼丄榁壔偵娭傢傞堎忢儈僩僐儞僪儕傾乮Mt乯拁愊傪敽偆恡忈奞傪擣傔丄偙傟傜偼12儢寧楊偐傜峏偵12儢寧娫偺CR乮捠忢怘偺60亾検傪愛庢乯偵偰桳堄偵夵慞偝傟偨丅壛楊恡擜嵶娗嵶朎偱偼丄掅巁慺忬懺偱庝婲偝傟傞傋偒嵶朎撪忩壔婡峔偱偁傞僆乕僩僼傽僕乕妶惈偺忈奞偑擣傔傜傟丄峏偵丄偙偺攚宨偵偼僀儞僗儕儞僔僌僫儖偺槾恑丄峈榁壔暘巕Sirt1妶惈偺掅壓傪夘偟偨揮幨場巕Foxo3偺揮幨妶惈壔堎忢丄偦傟偵敽偆僆乕僩僼傽僕乕娭楢暘巕Bnip3敪尰偺掅壓偑娭梌偟偆傞偙偲偑妋擣偝傟偨丅堦曽丄CR儅僂僗偺恡擜嵶娗嵶朎偱偼丄Sirt1偺妶惈壔丄掅巁慺偵傛傞僆乕僩僼傽僕乕偺妶惈壔擻偑曐帩偝傟丄堎忢Mt偺攔彍偑懀恑偝傟偰偄傞帠偑柧傜偐偲側偭偨丅Sirt1+/-儅僂僗傪梡偄偨専摙偐傜丄壛楊恡偱偺CR偵傛傞僆乕僩僼傽僕乕妶惈偺夵慞嶌梡偵Sirt1偑晄壜寚偱偁傞帠傕妋擣偝傟丄恡憻偵偍偗傞Sirt1-僆乕僩僼傽僕乕宱楬偺栶妱丄壛楊偵敽偆擜嵶娗嵶朎偺僗僩儗僗墳摎忈奞偺暘巕婡峔偑柧傜偐偲側偭偨丅
嬤擭丄僆乕僩僼傽僕乕偑奺憻婍偵偍偗傞條乆側惗棟嶌梡傗昦懺宍惉偵娭梌偟偆傞偲偺曬崘偑側偝傟偰偍傝丄崱夞変乆偼怴偨偵恡憻偵偍偗傞僆乕僩僼傽僕乕偺栶妱傪帵偟偨丅崱屻丄偙傟傜偺抦尒傪尦偵丄Sirt1-僆乕僩僼傽僕乕宱楬偲枬惈恡憻昦恑揥傊偺娭傢傝傪専摙偟丄杮宱楬偺妶惈壔傪昗揑偲偟偨怴偨側枬惈恡憻昦帯椕偺壜擻惈傪妋棫偟偨偄偲峫偊偰偄傞丅
暥愑丂撪壢妛島嵗乛惗壔妛丒暘巕惗暔妛島嵗丂媣暷恀巌
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