| Yoshihiko Shimizu, Dean Thumkeo, Jeongsin Keel, Toshimasa Ishizaki, Hiroko Oshima, Masanobu Oshima, Yoichi Noda, Fumio Matsumura, Makoto M. Taketo, Shuh Narumiya |
| ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles |
| J. Cell Biol.2005;168(6):941-953
PMID: 15764699 |
|
| ROCK- I偼戀帣婜偺娽豳暵嵔丄惗棟揑鋊懷僿儖僯傾暵嵔傪惂屼偡傞 |
亂梫巪亃
暘巕嵶朎惗暔妛偼惗暔偺懱傪峔惉偡傞暔幙偺峔憿傗摥偒傪夝柧偡傞偙偲偵傛偭偰惗柦尰徾偺杮幙傪棟夝偟傛偆偲偡傞妛栤偱偡丅変乆偼暘巕嵶朎惗暔妛揑幚尡庤朄傪傕偪偄偰1996擭偵敪尒偝傟偨Rho associated coiled-coil forming protein kinase (ROCK)偲偄偆堚揱巕偺摥偒傪柧傜偐偵偟丄偦傟傜偺抦尒傪帯椕傗憂栻偵惗偐偟偨偄偲峫偊偰偄傑偡丅
Rho偼备凛嵶朎崪奿偺嵞曇惉傪夘偟偰丄嵶朎塣摦丒愙拝丒嵶朎幙暘楐側偳懡偔偺嵶朎斀墳偺挷愡暘巕偲偟偰婡擻偟偰偄傑偡丅ROCK偼偙偺Rho偵傛傝妶惈壔偝傟丄Rho偵傛傞备凛嵶朎崪奿偺嵞曇惉傪拞宲偡傞暘巕偱偁傞偙偲偑in vitro偱帵偝傟偰偄傑偟偨丅备凛偼嵶朎枌捈壓偺庡梫側嵶朎崪奿偱偁傝丄恀妀嵶朎偺宍懺曄壔丄嵶朎塣摦偵晄壜寚側傕偺偱偁傞偙偲偐傜丄ROCK偺惗懱撪偱偺廳梫惈偑梊憐偝傟偰偄傑偟偨丅幚嵺丄尰嵼傑偱ROCK摿堎揑慾奞栻偱偁傞Y-27632傪梡偄偰悢懡偔偺ROCK偺惗懱撪偱偺婡擻偑夝柧偝傟偰偒傑偟偨丅ROCK偼崅寣埑徢丄婥娗巟歜懅丄擼寣娗澒弅丄寣彫斅婡擻丄嵶朎偺埆惈壔丄娻怹弫偵娭梌偡傞偙偲偑崙撪奜偺悢懡偔偺尋媶幰偵傛傝徹柧偝傟丄Y-27632偺帯椕傊偺墳梡偑婜懸偝傟偰偄傑偡丅
堦曽丄偙傟傑偱敪惗偵偍偗傞ROCK-I偺栶妱偼傎偲傫偳柧傜偐偵偝傟偰偄傑偣傫偱偟偨丅傢傟傢傟偼歁擕椶偺敪惗偵偍偄偰ROCK-I偑壥偨偡栶妱傪挷傋傞偨傔偵丄ROCK-I堚揱巕傪攋夡偟偨ROCK-I莎副衬铣絺饙鞇瑐祩軅祩絹BROCK-I莎副衬铣絺蛻賻檴鷤虋後贂聧絹A惗棟揑鋊懷唾票暵嵔偵堎忢傪偒偨偟丄怴惗帣婜偵巰朣偡傞偲偄偆昞尰宆傪帵偟傑偟偨丅戀帣婜偺娽豳暵嵔丄惗棟揑鋊懷唾票暵嵔偵偼备凛嵶朎崪奿偑偦傟偧傟偺応強偱兽菽挢莞�(备凛偑港截莞偟偰懢偔側傞偙偲)偑昁梫偱偁傞偙偲丄ROCK-I莎副衬铣絺艂蛡眰淌掭霓剌皋偑惓忢偵峴傢傟側偄偨傔偵娽豳暵嵔丄惗棟揑鋊懷唾票暵嵔偑惓忢偵峴傢傟側偄偙偲偑傢偐傝傑偟偨丅偡側傢偪丄ROCK-I偼敪惗帪婜偺惗懱撪偵偍偄偰傕丄兽菽挢莞迋苽A备凛嵶朎崪奿偺嵞曇惉偵娭梌偟偰偄傞偙偲偑柧傜偐偲側傝傑偟偨丅傑偨丄惗棟揑鋊懷唾票偺暵嵔堎忢(四偵偍偄偰偼怴惗帣鋊懷唾票)偲偄偆梊屻偺埆偄幘姵偺尨場偺傂偲偮偑ROCK-I偱偁傞偙偲傕敾柧偟傑偟偨丅
杮尋媶偑昡壙偝傟偨偺偼丄1) 莎副衬铣絺饙鞇瑐祩腞OCK-I偺摥偒傪捈愙揑偵徹柧偟偨偙偲丄2) 梊憐偝傟偰偄偨ROCK-I偺惗懱撪偱偺备凛嵶朎崪奿嵞曇惉傪徹柧偟偨偙偲丄3) ROCK-I偑怴惗帣鋊懷唾票偺尨場堚揱巕偺傂偲偮偱偁傞偙偲傪徹柧偟偨偙偲丄偲峫偊偰偄傑偡丅
暥愑丂帬夑堛壢戝妛戝妛堾4擭惗乮嶻壢妛晈恖壢妛島嵗乯惔悈丂椙旻 |
|
